Breast cancer is heterogeneous, not homogeneous. There are subtypes that are more deadly and less receptive to current therapies, including a variety known as triple negative breast cancer. Most breast cancers are fueled by three hormonal ‘receptors;’ estrogen, progesterone, or human epidermal growth factor receptor 2 (HER2). Consequently, most successful treatments target these receptors. A triple negative breast cancer diagnosis means that the cancer was not triggered by hormonal receptors. Triple negative breast cancer represents about 15% to 25% of all breast cancer cases, so it’s not exactly an orphan disease, even if I’d never heard of it. Among younger women triple negative breast cancer disproportionately affects African Americans, and their prognosis is worse than for women from other ethnic groups. While triple negative breast cancer responds well to chemotherapy, in some cases early complete response does not correlate with survival rates. And so it’s especially challengin...
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